Clerodendrum phlomidis has been mentioned for many disorders. However no references are available regarding the toxicity study of this herb. So we confined our work on acute toxicity studies of aqueous extract of Clerodendrum phlomidis Linn. (AECP) roots in albino mice Method: Albino mice of either sex were divided into four groups 1st group given plain water and 2nd, 3rd, 4th given 100, 300 and 1000 mg of AECP per 100 gm body weight in single dose respectively. After 72 hour of dose blood sample taken to determine haemoglobin, RBC count, WBC count, blood urea, blood glucose, serum creatinine, serum cholesterol, S.G.P.T and S.G.O.T. Gross and histological examination done by veterinary pathologist. Result: Results indicated that AECP did not have lethal effect upon 100 times of the therapeutic dose in albino mice. Although not dose dependent, this extract produced significant abnormality in liver and kidney. Fatty changes occurred in the kidneys. S.G.P.T level increased markedly. Fasting blood sugar continued to show inconsistent tendency toward hypoglycemia. Conclusion: AECP did not have any lethal effect up to 100 times of the therapeutic dose in the Albino mice.
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